The Duke Division of Pulmonary, Allergy, and Critical Care Medicine is actively engaged in clinical research activities to advance our knowledge about the diagnosis and treatment of airway invasion by lung cancer and malignant pleural effusions.

Current Clinical Trials

Select a trial to read the full description on the clinicaltrials.gov Web site:

• Impact of Aggressive Versus Standard Drainage Regimen Using a Long-Term Indwelling Pleural Catheter (ASAP): The purpose of this study is to determine if the rate of spontaneous pleurodesis using the Pleurx® catheter could be increased by simply increasing the frequency of pleural drainage and, if so, whether catheter-related complications can be minimized and spare patients the need for long-term management of the Pleurx® catheter.
  
  Principal Investigator: Momen Wahidi, MD, MBA
  Sub-Investigator: Scott Shofer, MD, PhD

• Study Using a Genomic Predictor of Platinum Resistance to Guide Therapy in Stage IIIB/IV Non-Small Cell Lung Cancer (TOP0602): This study will assign subjects with chemo-naive advanced non-small cell lung cancer (NSCLC) to chemotherapy using a genomic-based predictor to determine platinum sensitivity. Subjects with squamous cell NSCLC who are sensitive to cisplatin will receive cisplatin/gemcitabine, and if resistant to cisplatin will receive docetaxel/gemcitabine. Subjects with non-squamous cell NSCLC who are sensitive to cisplatin will receive cisplatin/pemetrexed, and if resistant to cisplatin will receive pemetrexed/gemcitabine.
  
  Sub-Investigator: Momen Wahidi, MD, MBA

Enroll in a Pulmonary Clinical Trial at Duke

Researchers in our division are investigating a variety of treatments and therapies to respond to lung disease. For a list of current pulmonary-related clinical trials, visit DukeHealth.org.