Claude A. Piantadosi, MD


Professor of Medicine
Professor of Pathology
Assistant Professor in Anesthesiology
Department / Division:
Medicine / Medicine-Pulmonary
Address:
DUMC 3315
Durham, NC 27710
Appointment Telephone:
919-620-5300
Office Telephone:
919-684-6143
Fax:
919-684-6002
Training:
  • MD, Johns Hopkins University School of Medicine (Maryland), 1975
Residency:
  • Medicine, Johns Hopkins Hospital (Maryland), 1975-1977
  • Pulmonary and Critical Care Medicine, Duke University Medical Center, 1980-1981
Clinical Interests:
Critical care medicine, interstitial lung diseases, sarcoidosis, pulmonary alveolar proteinosis, diving/hyperbaric medicine
Research Interests:
Dr. Piantadosi's laboratory has special expertise in the pathogenic mechanisms of acute organ failure, particularly acute lung injury (ALI), with an emphasis on the molecular regulatory roles of the physiological gases— oxygen, carbon monoxide, and nitric oxide— as they relate to the damage responses to acute inflammation. The basic science focuses on oxidative processes and redox-regulation, especially the molecular mechanisms by which reactive oxygen and nitrogen species transmit biological signals involved in the maintenance of energy metabolism and mitochondrial health, but also contribute to pathogenesis and to the resolution of tissue injury.

Clinically, ALI and the related syndrome of multiple organ failure has a high mortality, which is related to the host inflammatory response, but is not well understood scientifically; thus, the laboratory is devoted to understanding these mechanisms in the context of the host response to relevant but well-controlled experimental manipulations including hyperoxia, bacterial infections, toxic drugs, and cytokine/chemokine signals. The approach relies on animal models, mainly transgenic and knockout mice, and cell models, especially lung and heart cells to evaluate and understand the physiology, pathology, and cell and molecular biology of the injury responses, to test independent and integrated mechanisms, and to devise interventions to prevent damage.

Apart from the lung, significant work is devoted to understanding damage to the heart, brain, liver, and kidney caused by these immune mechanisms, specifically emphasizing the role of mitochondria, key targets and sources of oxidative damage. This damage compromises their ability to support energy homeostasis and advanced cellular functions, and impacts on the important roles these organelles play in cell death by apoptosis and necrosis as well as in the resolution of cellular damage and inflammation.
Representative Publications:
  • Piantadosi, CA. Regulation of mitochondrial processes by protein S-nitrosylation. Biochimica et Biophysica Acta: international journal of biochemistry and biophysics. 2012;1820:712-721.  Abstract
  • Bartz, RR; Suliman, HB; Fu, P; Welty-Wolf, K; Carraway, MS; MacGarvey, NC; Withers, CM; Sweeney, TE; Piantadosi, CA. Staphylococcus aureus sepsis and mitochondrial accrual of the 8-oxoguanine DNA glycosylase DNA repair enzyme in mice. American Journal of Respiratory and Critical Care Medicine. 2011;183:226-233.  Abstract
  • Piantadosi, CA; Withers, CM; Bartz, RR; MacGarvey, NC; Fu, P; Sweeney, TE; Welty-Wolf, KE; Suliman, HB. Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression. Journal of Biological Chemistry. 2011;286:16374-16385.  Abstract
  • Sheng, H; Reynolds, JD; Auten, RL; Demchenko, IT; Piantadosi, CA; Stamler, JS; Warner, DS. Pharmacologically augmented S-nitrosylated hemoglobin improves recovery from murine subarachnoid hemorrhage. Stroke. 2011;42:471-476.  Abstract
  • Sweeney, TE; Suliman, HB; Hollingsworth, JW; Welty-Wolf, KE; Piantadosi, CA. A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis. PLoS One. 2011;6:e25249.  Abstract
  • Carraway, MS; Suliman, HB; Jones, WS; Chen, CW; Babiker, A; Piantadosi, CA. Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart. Circulation Research. 2010;106:1722-1730.  Abstract
  • Carré, JE; Orban, JC; Re, L; Felsmann, K; Iffert, W; Bauer, M; Suliman, HB; Piantadosi, CA; Mayhew, TM; Breen, P; Stotz, M; Singer, M. Survival in critical illness is associated with early activation of mitochondrial biogenesis. American Journal of Respiratory and Critical Care Medicine. 2010;182:745-751.  Abstract
  • Suliman, HB; Sweeney, TE; Withers, CM; Piantadosi, CA. Co-regulation of nuclear respiratory factor-1 by NFkappaB and CREB links LPS-induced inflammation to mitochondrial biogenesis. Journal of Cell Science. 2010;123:2565-2575.  Abstract
  • Allen, BW; Stamler, JS; Piantadosi, CA. Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation. Trends in Molecular Medicine. 2009;15:452-460.  Abstract
  • Reynolds, CM; Suliman, HB; Hollingsworth, JW; Welty-Wolf, KE; Carraway, MS; Piantadosi, CA. Nitric oxide synthase-2 induction optimizes cardiac mitochondrial biogenesis after endotoxemia. Free Radical Biology and Medicine. 2009;46:564-572.  Abstract
  • Gutsaeva, DR; Carraway, MS; Suliman, HB; Demchenko, IT; Shitara, H; Yonekawa, H; Piantadosi, CA. Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism. The Journal of Neuroscience. 2008;28:2015-2024.  Abstract
  • Piantadosi, CA. Carbon monoxide, reactive oxygen signaling, and oxidative stress. Free Radical Biology and Medicine. 2008;45:562-569.  Abstract
  • Piantadosi, CA; Carraway, MS; Babiker, A; Suliman, HB. Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. Circulation Research. 2008;103:1232-1240.  Abstract
  • Demchenko, IT; Welty-Wolf, KE; Allen, BW; Piantadosi, CA. Similar but not the same: normobaric and hyperbaric pulmonary oxygen toxicity, the role of nitric oxide. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2007;293:L229-L238.  Abstract
  • Haden, DW; Suliman, HB; Carraway, MS; Welty-Wolf, KE; Ali, AS; Shitara, H; Yonekawa, H; Piantadosi, CA. Mitochondrial biogenesis restores oxidative metabolism during Staphylococcus aureus sepsis. American Journal of Respiratory and Critical Care Medicine. 2007;176:768-777.  Abstract
  • Piantadosi, CA. Early development of near-infrared spectroscopy at Duke University. Journal of Biomedical Optics. 2007;12:062102.  Abstract
  • Suliman, HB; Carraway, MS; Ali, AS; Reynolds, CM; Welty-Wolf, KE; Piantadosi, CA. The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy. Journal of Clinical Investigation. 2007;117:3730-3741.  Abstract
  • Suliman, HB; Carraway, MS; Tatro, LG; Piantadosi, CA. A new activating role for CO in cardiac mitochondrial biogenesis. Journal of Cell Science. 2007;120:299-308.  Abstract
  • Piantadosi, CA; Suliman, HB. Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1. Journal of Biological Chemistry. 2006;281:324-333.  Abstract
  • Welty-Wolf, KE; Carraway, MS; Ortel, TL; Ghio, AJ; Idell, S; Egan, J; Zhu, X; Jiao, JA; Wong, HC; Piantadosi, CA. Blockade of tissue factor-factor X binding attenuates sepsis-induced respiratory and renal failure. American Journal of Physiology: Lung Cellular and Molecular Physiology. 2006;290:L21-L31.  Abstract
  • Suliman, HB; Welty-Wolf, KE; Carraway, MS; Schwartz, DA; Hollingsworth, JW; Piantadosi, CA. Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli. The FASEB Journal. 2005;19:1531-1533.  Abstract
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